Author Archives: Catherine Zandonella

How the ice ages ended (Nature)

by Cather­ine Zan­donella, Office of the Dean for Research

Antarctica. Photo credit: Harley D. Nygren, NOAA

Antarc­tica. Photo credit: Harley D. Nygren, NOAA

A study of sed­i­ment cores col­lected from the deep ocean sup­ports a new expla­na­tion for how glac­ier melt­ing at the end of the ice ages led to the release of car­bon diox­ide from the ocean.

The study pub­lished in Nature sug­gests that melt­ing glac­i­ers in the north­ern hemi­sphere caused a dis­rup­tion of deep ocean cur­rents, lead­ing to the release of trapped car­bon diox­ide from the South­ern Ocean around Antarctica.

Under­stand­ing what hap­pened when pre­vi­ous glac­i­ers melted could help cli­mate researchers make accu­rate pre­dic­tions about future global tem­per­a­ture increases and their effects on the planet.

The evi­dence is strong that ice ages are dri­ven by peri­odic changes in the amount of sun­light reach­ing the poles due to cyclic changes in Earth’s rota­tion and orbit. Yet sci­en­tists have been puz­zled by evi­dence that although the tim­ing of ice ages are best explained by changes in sun­light in the north­ern part of the globe, the warm­ing at the end of ice ages occurred first in the south­ern hemi­sphere, with a rise in car­bon diox­ide lev­els appear­ing to be cued from the south.

The new study sug­gests that changes in ocean cur­rents, con­nect­ing the north to the south through the deep ocean, were to blame.

As glaciers melted in the northern reaches of the globe (far upper left), the influx of freshwater, which is naturally less dense than salt-laden ocean water, reduced the normally strong sinking of water in that region. This allowed silicate-rich deep water to rise upward into the shallower ocean waters (upward blue arrows), stimulating the production of opal by diatoms, while warm surface water mixed downward (red arrows) into the southern-sourced deep water. The rising silicate-rich water drew dense cold water from near Antarctica, yielding a cycle of water movement (in yellow). The new circulation pattern caused the carbon dioxide stored in the deep water to be released to the atmosphere near Antarctica (far upper right). Image source: Daniel Sigman.

As glac­i­ers melted in the north­ern reaches of the globe (far upper left), the influx of fresh­wa­ter, which is nat­u­rally less dense than salt-laden ocean water, caused a reduc­tion in the nor­mally strong sink­ing of water in that region. This allowed silicate-rich deep water to rise upward into the shal­lower ocean waters (upward blue arrows), stim­u­lat­ing the pro­duc­tion of opal by diatoms, while warm sur­face water mixed down­ward (red arrows) into the southern-sourced deep water. The ris­ing silicate-rich water drew dense cold water from near Antarc­tica, yield­ing a cycle of water move­ment (in yel­low). The new cir­cu­la­tion pat­tern caused car­bon diox­ide stored in the deep water to be released to the atmos­phere near Antarc­tica (far upper right). Image source: Daniel Sigman.

Part of this story was sug­gested more than a decade ago and is already accepted by many cli­mate sci­en­tists: As glac­i­ers in the north started melt­ing, the influx of fresh water diluted the salty waters that today flow to the north from the trop­ics as an exten­sion of the Gulf Stream. Nor­mally, these salty waters become cool and sink into the deep ocean, form­ing cold and dense water that flows south­ward, and allow­ing more salty trop­i­cal water to take its place in a sort of ocean con­veyor belt. But the influx of fresh water due to melt­ing glac­i­ers stalled the con­veyor belt.

So how did this lead to changes in the south­ern hemisphere?

The new research sug­gests that the shut­down in north­ern sink­ing water allowed southern-sourced water to fill up the deep Atlantic, set­ting up a new ocean cir­cu­la­tion pat­tern. This new cir­cu­la­tion pat­tern brought deep-sea water, which was rich in car­bon diox­ide due to sunken dead marine algae, to the sur­face near Antarc­tica, where the gas escaped into the atmos­phere and acted to drive global warm­ing.  (See diagram.)

The researchers included inves­ti­ga­tors from ETH Zürich, Prince­ton Uni­ver­sity, the Uni­ver­sity of Miami, the Uni­ver­sity of British Colum­bia, and the Uni­ver­sity of Bre­men and the Alfred Wegener Insti­tute in Ger­many. The Prince­ton effort was led by Daniel Sig­man, the Dusen­bury Pro­fes­sor of Geo­log­i­cal and Geo­phys­i­cal Sciences.

The team tracked these his­toric move­ments of water through the study of sed­i­ment cores that are rich in sil­i­con diox­ide, or opal. Tiny marine algae known as diatoms make their cell walls out of opal, and when the organ­isms die, their opal remains sink to the deep sea bed.

The researchers looked at opal in sed­i­ment core sam­ples drilled from deep beneath the ocean floor off the coast of north­west Africa and Antarc­tica. The team found that each period of glac­ier melt­ing, which occurred five times over the last 550 thou­sand years, cor­re­sponded to a spike in the amount of the opal in the sed­i­ment, sig­nal­ing an increase in diatom growth. The tim­ing of the opal spikes pro­vides evi­dence that the deep, opal-rich waters in the south were drawn to the sur­face in response to new melt­wa­ter enter­ing the north­ern ocean.

The mech­a­nism clashes with a pre­vi­ously offered expla­na­tion of why the melt­ing of the north­ern glac­i­ers, or deglacia­tions, leads to the release of ocean car­bon diox­ide from the South­ern Ocean – the the­ory that the melt­ing glac­i­ers in the north increased south­ern hemi­sphere west­erly winds, which in turn caused upwelling of South­ern Ocean deep waters. “While dis­tin­guish­ing between these alter­na­tives is impor­tant,” says Sig­man, “the greater chal­lenge is to test and under­stand a premise that is shared by both of these sce­nar­ios: that ice age con­di­tions around Antarc­tica caused the deep ocean to be slug­gish and rich in car­bon diox­ide. If this was really how the ice age ocean oper­ated, then it calls for us to recon­sider how we expect deep ocean cir­cu­la­tion to respond to mod­ern global warming.”

Read the abstract.

A. N. Meck­ler, D. M. Sig­man, K. A. Gib­son, R. François, A. Martínez-García, S. L. Jac­card, U. Röhl, L. C. Peter­son, R. Tiede­mann & G. H. Haug. 2013. Deglacial pulses of deep-ocean sil­i­cate into the sub­trop­i­cal North Atlantic Ocean. Nature 495 (7442), 495–498. doi:10.1038/nature12006. Pub­lished online 27 March, 2013.

This research used sam­ples pro­vided by the ODP, which is spon­sored by the US National Sci­ence Foun­da­tion (NSF) and par­tic­i­pat­ing coun­tries under the man­age­ment of the Joint Oceano­graphic Insti­tu­tions. XRF data were acquired at the XRF Core Scan­ner Lab at MARUM – Cen­ter for Marine Envi­ron­men­tal Sci­ences, Uni­ver­sity of Bre­men, with sup­port from the DFG-Leibniz Cen­ter for Sur­face Process and Cli­mate Stud­ies at the Uni­ver­sity of Pots­dam. Fur­ther sup­port was pro­vided by the US NSF through grant OCE-1060947 to D.M.S. and by NSERC and CFCAS to R.F.

Shape from sound — new methods to probe the universe (Physical Review Letters)

By Mor­gan Kelly, Office of Communications

As the uni­verse expands, it is con­tin­u­ally sub­jected to energy shifts, or “quan­tum fluc­tu­a­tions,” that send out lit­tle pulses of “sound” into the fab­ric of space­time. In fact, the uni­verse is thought to have sprung from just such an energy shift.

A recent paper in the jour­nal Phys­i­cal Review Let­ters reports a new math­e­mat­i­cal tool that should allow one to use these sounds to help reveal the shape of the uni­verse. The authors recon­sider an old ques­tion in spec­tral geom­e­try that asks, roughly, to what extent can the shape of a thing be known from the sound of its acoustic vibra­tions? The researchers approached this prob­lem by break­ing it down into small work­able pieces, accord­ing to author Tejal Bhamre, a Prince­ton Uni­ver­sity grad­u­ate stu­dent in the Depart­ment of Physics.

To under­stand the authors’ method, con­sider a vase. If one taps a vase with a spoon, it will make a sound that is char­ac­ter­is­tic of its shape. Sim­i­larly, the tech­nique Bhamre and her coau­thors devel­oped could, in prin­ci­ple, deter­mine the shape of space­time from the per­pet­ual ring­ing caused by quan­tum fluctuations.

The researchers’ tech­nique also pro­vides a unique con­nec­tion between the two pil­lars of mod­ern physics — quan­tum the­ory and gen­eral rel­a­tiv­ity — by using vibra­tional wave­lengths to define the geo­met­ric prop­erty that is spacetime.

Bhamre worked with coau­thors David Aasen, a physics grad­u­ate stu­dent at Cal­tech, and Achim Kempf, a Water­loo Uni­ver­sity pro­fes­sor of physics of information.

Read the abstract.

David Aasen, Tejal Bhamre and Achim Kempf. 2013. Shape from Sound: Toward New Tools for Quan­tum Grav­ity. Phys­i­cal Review Let­ters. Arti­cle first pub­lished online: March 18, 2013. DOI: 10.1103/PhysRevLett.110.121301.

This research was sup­ported by the Nat­ural Sci­ences and Engi­neer­ing Research Coun­cil of Canada.

Serendipity Pays Off (Science)

By Cather­ine Zan­donella, Office of the Dean for Research

Serendip­ity –­­ the act of find­ing some­thing good or use­ful while not specif­i­cally search­ing for it – can some­times pay off. Now Prince­ton Uni­ver­sity chem­istry researchers report that this non-specific type of search­ing has yielded a new method of build­ing mol­e­cules for use in new drugs, new agri­cul­tural chem­i­cals and even new perfumes.

In a paper pub­lished today in the jour­nal Sci­ence, Princeton’s David MacMil­lan and his team describe the dis­cov­ery of a new chem­i­cal reac­tion – not noted before in nature or in any lab – that could assist phar­ma­ceu­ti­cal chemists and oth­ers who rou­tinely cre­ate new chem­i­cals for a vari­ety of industries.

Until now, no one real­ized this chem­i­cal reac­tion – which involves adding atoms to a spe­cific car­bon atom on a mol­e­cule – could occur, accord­ing to MacMil­lan, the James S. McDon­nell Dis­tin­guished Uni­ver­sity Pro­fes­sor of Chem­istry at Prince­ton. “If you show this chem­i­cal reac­tion to most chemists, they imme­di­ately say ‘that’s impos­si­ble,’” MacMil­lan said.

In this case, the team dis­cov­ered this “impos­si­ble” reac­tion using an approach MacMil­lan pio­neered that he calls “accel­er­ated serendip­ity.” The researchers use robotic arms to con­duct thou­sands of reac­tions per day by com­bin­ing in test tubes dif­fer­ent com­bi­na­tions of chem­i­cals along with cat­a­lysts that spur the reac­tions. When the inves­ti­ga­tors find a reac­tion that makes an inter­est­ing prod­uct, they study it to under­stand how the reac­tion occurs.

We didn’t invent this new reac­tion – nature did that,” MacMil­lan said, “but we fig­ured out how to get the reac­tion to hap­pen in the lab.” said MacMil­lan. His team, which included grad­u­ate stu­dent Michael Pirnot, post­doc­toral researcher David Mar­tin and for­mer post­doc­toral researcher Dan­ica Ran­kic, uses ordi­nary light bulbs as cat­a­lysts, a tech­nique devel­oped in MacMillan’s lab and pub­lished in Sci­ence in 2008, to spur the reactions.

Going for­ward, chemists can add this new reac­tion to their tool box of meth­ods for build­ing up mol­e­cules, which they do in a way anal­o­gous to join­ing together pieces of Kinex or Tin­ker Toys, by swap­ping in new parts to increase the func­tion of the mol­e­cule. In the new reac­tion pub­lished today, the team dis­cov­ered a way to join so-called “func­tional groups” to a spe­cific car­bon atom (see dia­gram) in larger struc­tures known as ketones and alde­hy­des. The abil­ity to add func­tional groups to that car­bon atom was thought impos­si­ble until now.

macmillan

Cap­tion: Upper and lower left: Green spots indi­cate car­bon atoms known to undergo reac­tions. Right panel: Pur­ple spot indi­cates a car­bon atom thought not to undergo reac­tions. The team dis­cov­ered, using accel­er­ated serendip­ity, a way to cause this car­bon to react, result­ing in addi­tion of func­tional groups, and poten­tially lead­ing to new drugs or other impor­tant indus­trial chem­i­cals. (Source: Science)

This new chem­i­cal reac­tion has wide appli­ca­tions, MacMil­lan said. “This is a fun­da­men­tal reac­tion which any chemist can start using.”

For exam­ple, a chemist who is build­ing a drug to treat Alzheimer’s dis­ease might desire to add a chem­i­cal group to the reluc­tant car­bon atom. Nor­mally that would require the chemist to con­duct sev­eral dif­fer­ent chem­i­cal reac­tions over sev­eral weeks, but with the new reac­tion the chemist could build the drug in two days and be test­ing drug can­di­dates much more quickly.

Sim­i­larly a chemist at a fra­grance com­pany could use the new reac­tion to exper­i­ment with the cre­ation of new per­fume formulations.

MacMillan’s orig­i­nal paper on accel­er­ated serendip­ity, pub­lished in 2011 in Sci­ence, suc­cess­fully dis­cov­ered a reac­tion now used in the drug indus­try. Yet it was con­tro­ver­sial because other sci­en­tists inter­preted the robotic searches as ran­dom searches, when in fact they were not ran­dom. “We chose chem­i­cals that had never been shown to react with each other – those are the ones we believe might lead to as-yet undis­cov­ered reac­tions.” MacMil­lan said that these reac­tions may have been cre­ated in the past by chemists who didn’t rec­og­nize what they were.

Read the abstract.

Michael T. Pirnot, Dan­ica A. Ran­kic, David B. C. Mar­tin, David W. C. MacMil­lan. Pho­tore­dox Acti­va­tion for the Direct β-Ary­la­tion of Ketones and Alde­hy­des. Sci­ence 29 March 2013. Vol. 339 no. 6127 pp. 1593–1596.

This research was sup­ported by the National Insti­tute of Gen­eral Med­ical Sci­ences grant R01 GM103558-01 and gifts from Merck, Amgen, Abbott, and Bristol-Myers Squibb.

Younger cancer patients experience greater increase in religiosity (Social Science Research)

By Michael Hotchkiss, Office of Communications

Peo­ple diag­nosed with can­cer at younger ages are more likely to become more reli­gious than their coun­ter­parts diag­nosed at older ages, researchers includ­ing a Prince­ton research scholar have found.

Over­all, the researchers found that peo­ple diag­nosed with can­cer expe­ri­enced a one-time increase in reli­gios­ity, with the greater increase among those who expe­ri­enced a diag­no­sis at a younger age, what’s known as an “off-time diagnosis.”

“Off-time diag­noses may also be related to increased reli­gios­ity because the mean­ing of hav­ing can­cer may be dif­fer­ent for those in mid­dle adult­hood com­pared to older adult­hood,” the researchers said. The results come from a review of sur­veys of more than 3,400 peo­ple con­ducted in 1994–95 and 2004-06.

The research, detailed in an arti­cle in the March issue of Social Sci­ence Research, was con­ducted by Michael McFar­land, a post­doc­toral researcher at Princeton’s Office of Pop­u­la­tion Research, Tetyana Pudrovska, an assis­tant pro­fes­sor at Penn­syl­va­nia State Uni­ver­sity; Scott Schie­man, a pro­fes­sor at the Uni­ver­sity of Toronto; Christo­pher Elli­son, a pro­fes­sor at the the Uni­ver­sity of Texas at San Anto­nio; and Alex Bier­man, an assis­tant pro­fes­sor at the Uni­ver­sity of Calgary.

Read the abstract.

McFar­land, Michael J., Tetyana Pudrovska, Scott Schie­man, Christo­pher G. Elli­son, and Alex Bier­man. March 2013. Does a can­cer diag­no­sis influ­ence reli­gios­ity? Inte­grat­ing a life course per­spec­tive. Social Sci­ence Research. Vol. 42, Issue 2, pp. 311–20.

Drug-resistant MRSA bacteria — here to stay in both hospital and community (PLoS Pathogens)

By Cather­ine Zan­donella, Office of the Dean for Research

A colorized scanning electron micrograph of a white blood cell eating an antibiotic resistant strain of Staphylococcus aureus bacteria, commonly known as MRSA. (Source: National Institute of Allergy and Infectious Diseases (NIAID))

A col­orized scan­ning elec­tron micro­graph of a white blood cell eat­ing an antibi­otic resis­tant strain of Staphy­lo­coc­cus aureus bac­te­ria, com­monly known as MRSA. (Source: National Insti­tute of Allergy and Infec­tious Dis­eases (NIAID))

The drug-resistant bac­te­ria known as MRSA, once con­fined to hos­pi­tals but now wide­spread in com­mu­ni­ties, will likely con­tinue to exist in both set­tings as sep­a­rate strains, accord­ing to a new study.

The pre­dic­tion that both strains will coex­ist is reas­sur­ing because pre­vi­ous pro­jec­tions indi­cated that the more inva­sive and fast-growing com­mu­nity strains would over­take and elim­i­nate hos­pi­tal strains, pos­si­bly pos­ing a threat to pub­lic health.

Researchers at Prince­ton Uni­ver­sity used math­e­mat­i­cal mod­els to explore what will hap­pen to com­mu­nity and hos­pi­tal MRSA strains, which dif­fer genet­i­cally.  Orig­i­nally MRSA, which is short for methicillin-resistant Staphy­lo­coc­cus aureus, was con­fined to hos­pi­tals. How­ever, community-associated strains emerged in the past decade and can spread widely from per­son to per­son in schools, ath­letic facil­i­ties and homes.

Both com­mu­nity and hos­pi­tal strains cause dis­eases rang­ing from skin and soft-tissue infec­tions to pneu­mo­nia and sep­ticemia. Hos­pi­tal MRSA is resis­tant to numer­ous antibi­otics and is very dif­fi­cult to treat, while com­mu­nity MRSA is resis­tant to fewer antibiotics.

The new study found that these dif­fer­ences in antibi­otic resis­tance, com­bined with more aggres­sive antibi­otic usage pat­terns in hos­pi­tals ver­sus the com­mu­nity set­ting, over time will per­mit hos­pi­tal strains to sur­vive despite the com­pe­ti­tion from com­mu­nity strains. Hospital-based antibi­otic usage is likely to suc­cess­fully treat patients infected with com­mu­nity strains, pre­vent­ing the new­comer strains from spread­ing to new patients and gain­ing the foothold they need to out-compete the hos­pi­tal strains.

The researchers made their pre­dic­tions by using math­e­mat­i­cal mod­els of MRSA trans­mis­sion that take into account data on drug-usage, resis­tance pro­files, person-to-person con­tact, and patient age.

Pub­lished Feb­ru­ary 28 in the jour­nal PLOS Pathogens, the study was con­ducted by post­doc­toral researcher Roger Kouyos, now a scholar at the Uni­ver­sity of Zurich, and Eili Klein, a grad­u­ate stu­dent who is now an assis­tant pro­fes­sor in the Johns Hop­kins School of Med­i­cine. They con­ducted the work under the advise­ment of Bryan Gren­fell, Princeton’s Kathryn Briger and Sarah Fen­ton Pro­fes­sor of Ecol­ogy and Evo­lu­tion­ary Biol­ogy and Pub­lic Affairs at Princeton’s Woodrow Wil­son School of Inter­na­tional and Pub­lic Affairs.

Read the arti­cle (open access).

Kouyos R., Klein E. & Gren­fell B. (2013). Hospital-Community Inter­ac­tions Fos­ter Coex­is­tence between Methicillin-Resistant Strains of Staphy­lo­coc­cus aureus. PLoS Pathogens, 9 (2) e1003134. PMID:

RK was sup­ported by the Swiss National Sci­ence Foun­da­tion (Grants PA00P3_131498 and PZ00P3_142411). EK was sup­ported by Prince­ton Uni­ver­sity (Harold W. Dodds Fel­low­ship), as well as the Mod­els of Infec­tious Dis­ease Agent Study (MIDAS), under Award Num­ber U01GM070708 from the National Insti­tute of Gen­eral Med­ical Sci­ences. BG was sup­ported by the Bill and Melinda Gates Foun­da­tion; the Research and Pol­icy for Infec­tious Dis­ease Dynam­ics (RAPIDD) pro­gram of the Sci­ence and Tech­nol­ogy Direc­torate, Depart­ment of Home­land Secu­rity; and the Fog­a­rty Inter­na­tional Cen­ter, National Insti­tutes of Health.

Quantum computing moves forward (Science)

By Cather­ine Zan­donella, Office of the Dean for Research

New tech­nolo­gies that exploit quan­tum behav­ior for com­put­ing and other appli­ca­tions are closer than ever to being real­ized due to recent advances, accord­ing to a review arti­cle pub­lished this week in the jour­nal Sci­ence.

Science_cover

A sil­i­con chip lev­i­tates indi­vid­ual atoms used in quan­tum infor­ma­tion pro­cess­ing. Photo: Curt Suplee and Emily Edwards, Joint Quan­tum Insti­tute and Uni­ver­sity of Mary­land. Credit: Science.

These advances could enable the cre­ation of immensely pow­er­ful com­put­ers as well as other appli­ca­tions, such as highly sen­si­tive detec­tors capa­ble of prob­ing bio­log­i­cal sys­tems. “We are really excited about the pos­si­bil­i­ties of new semi­con­duc­tor mate­ri­als and new exper­i­men­tal sys­tems that have become avail­able in the last decade,” said Jason Petta, one of the authors of the report and an asso­ciate pro­fes­sor of physics at Prince­ton University.

Petta co-authored the arti­cle with David Awschalom of the Uni­ver­sity of Chicago, Lee Bas­set of the Uni­ver­sity of California-Santa Bar­bara, Andrew Dzu­rak of the Uni­ver­sity of New South Wales and Eve­lyn Hu of Har­vard University.

Two sig­nif­i­cant break­throughs are enabling this for­ward progress, Petta said in an inter­view. The first is the abil­ity to con­trol quan­tum units of infor­ma­tion, known as quan­tum bits, at room tem­per­a­ture. Until recently, tem­per­a­tures near absolute zero were required, but new diamond-based mate­ri­als allow spin qubits to be oper­ated on a table top, at room tem­per­a­ture. Diamond-based sen­sors could be used to image sin­gle mol­e­cules, as demon­strated ear­lier this year by Awschalom and researchers at Stan­ford Uni­ver­sity and IBM Research (Sci­ence, 2013).

The sec­ond big devel­op­ment is the abil­ity to con­trol these quan­tum bits, or qubits, for sev­eral sec­onds before they lapse into clas­si­cal behav­ior, a feat achieved by Dzurak’s team (Nature, 2010) as well as Prince­ton researchers led by Stephen Lyon, pro­fes­sor of elec­tri­cal engi­neer­ing (Nature Mate­ri­als, 2012). The devel­op­ment of highly pure forms of sil­i­con, the same mate­r­ial used in today’s clas­si­cal com­put­ers, has enabled researchers to con­trol a quan­tum mechan­i­cal prop­erty known as “spin”. At Prince­ton, Lyon and his team demon­strated the con­trol of spin in bil­lions of elec­trons, a state known as coher­ence, for sev­eral sec­onds by using highly pure silicon-28.

Quantum-based tech­nolo­gies exploit the phys­i­cal rules that gov­ern very small par­ti­cles — such as atoms and elec­trons — rather than the clas­si­cal physics evi­dent in every­day life. New tech­nolo­gies based on “spin­tron­ics” rather than elec­tron charge, as is cur­rently used, would be much more pow­er­ful than cur­rent technologies.

In quantum-based sys­tems, the direc­tion of the spin (either up or down) serves as the basic unit of infor­ma­tion, which is anal­o­gous to the 0 or 1 bit in a clas­si­cal com­put­ing sys­tem. Unlike our clas­si­cal world, an elec­tron spin can assume both a 0 and 1 at the same time, a feat called entan­gle­ment, which greatly enhances the abil­ity to do computations.

A remain­ing chal­lenge is to find ways to trans­mit quan­tum infor­ma­tion over long dis­tances. Petta is explor­ing how to do this with col­lab­o­ra­tor Andrew Houck, asso­ciate pro­fes­sor of elec­tri­cal engi­neer­ing at Prince­ton. Last fall in the jour­nal Nature, the team pub­lished a study demon­strat­ing the cou­pling of a spin qubit to a par­ti­cle of light, known as a pho­ton, which acts as a shut­tle for the quan­tum information.

Yet another remain­ing hur­dle is to scale up the num­ber of qubits from a hand­ful to hun­dreds, accord­ing to the researchers. Sin­gle quan­tum bits have been made using a vari­ety of mate­ri­als, includ­ing elec­tronic and nuclear spins, as well as superconductors.

Some of the most excit­ing appli­ca­tions are in new sens­ing and imag­ing tech­nolo­gies rather than in com­put­ing, said Petta. “Most peo­ple agree that build­ing a real quan­tum com­puter that can fac­tor large num­bers is still a long ways out,” he said. “How­ever, there has been a change in the way we think about quan­tum mechan­ics – now we are think­ing about quantum-enabled tech­nolo­gies, such as using a spin qubit as a sen­si­tive mag­netic field detec­tor to probe bio­log­i­cal systems.”

Read the abstract.

Awschalom D.D., Bas­sett L.C., Dzu­rak A.S., Hu E.L. & Petta J.R. (2013). Quan­tum spin­tron­ics: engi­neer­ing and manip­u­lat­ing atom-like spins in semi­con­duc­tors. Sci­ence 339 (6124) 1174–1179. PMID:

The research at Prince­ton Uni­ver­sity was sup­ported by the Alfred P. Sloan Foun­da­tion, the David and Lucile Packard Foun­da­tion, US Army Research Office grant W911NF-08–1-0189, DARPA QuEST award HR0011-09–1-0007 and the US National Sci­ence Foun­da­tion through the Prince­ton Cen­ter for Com­plex Mate­ri­als (DMR-0819860) and CAREER award DMR-0846341.

Researchers discover workings of brain’s ‘GPS system’ (Nature)

By Cather­ine Zan­donella, Office of the Dean for Research

Just as a global posi­tion­ing sys­tem (GPS) helps find your loca­tion, the brain has an inter­nal sys­tem for help­ing deter­mine the body’s loca­tion as it moves through its surroundings.

A new study from researchers at Prince­ton Uni­ver­sity pro­vides evi­dence for how the brain per­forms this feat. The study, pub­lished in the jour­nal Nature, indi­cates that cer­tain position-tracking neu­rons — called grid cells — ramp their activ­ity up and down by work­ing together in a col­lec­tive way to deter­mine loca­tion, rather than each cell act­ing on its own as was pro­posed by a com­pet­ing theory.

Grid cells are neu­rons that become elec­tri­cally active, or “fire,” as ani­mals travel in an envi­ron­ment. First dis­cov­ered in the mid-2000s, each cell fires when the body moves to spe­cific loca­tions, for exam­ple in a room. Amaz­ingly, these loca­tions are arranged in a hexag­o­nal pat­tern like spaces on a Chi­nese checker board.  (See figure.)

Tank_Brain_GPS

As the mouse moves around in a square arena (left), a sin­gle grid cell in the mouse’s brain becomes active, or spikes, when the ani­mal arrives at par­tic­u­lar loca­tions in the arena (right). These loca­tions are arranged in a hexag­o­nal pat­tern. The red dots indi­cate the mouse’s loca­tion in the arena when the grid cell fired. (Image credit: Cristina Dom­nisoru, Prince­ton University)

Together, the grid cells form a rep­re­sen­ta­tion of space,” said David Tank, Princeton’s Henry L. Hill­man Pro­fes­sor in Mol­e­c­u­lar Biol­ogy and leader of the study. “Our research focused on the mech­a­nisms at work in the neural sys­tem that forms these hexag­o­nal pat­terns,” he said. The first author on the paper was grad­u­ate stu­dent Cristina Dom­nisoru, who con­ducted the exper­i­ments together with post­doc­toral researcher Amina Kinkhabwala.

Dom­nisoru mea­sured the elec­tri­cal sig­nals inside indi­vid­ual grid cells in mouse brains while the ani­mals tra­versed a computer-generated vir­tual envi­ron­ment, devel­oped pre­vi­ously in the Tank lab. The ani­mals moved on a mouse-sized tread­mill while watch­ing a video screen in a set-up that is sim­i­lar to video-game vir­tual real­ity sys­tems used by humans.

She found that the cell’s elec­tri­cal activ­ity, mea­sured as the dif­fer­ence in volt­age between the inside and out­side of the cell, started low and then ramped up, grow­ing larger as the mouse reached each point on the hexag­o­nal grid and then falling off as the mouse moved away from that point.

This ramp­ing pat­tern cor­re­sponded with a pro­posed mech­a­nism of neural com­pu­ta­tion called an attrac­tor net­work. The brain is made up of vast num­bers of neu­rons con­nected together into net­works, and the attrac­tor net­work is a the­o­ret­i­cal model of how pat­terns of con­nected neu­rons can give rise to brain activ­ity by col­lec­tively work­ing together. The attrac­tor net­work the­ory was first pro­posed 30 years ago by John Hop­field, Princeton’s Howard A. Prior Pro­fes­sor in the Life Sci­ences, Emeritus.

The team found that their mea­sure­ments of grid cell activ­ity cor­re­sponded with the attrac­tor net­work model but not a com­pet­ing the­ory, the oscil­la­tory inter­fer­ence model. This com­pet­ing the­ory pro­posed that grid cells use rhyth­mic activ­ity pat­terns, or oscil­la­tions, which can be thought of as many fast clocks tick­ing in syn­chrony, to cal­cu­late where ani­mals are located. Although the Prince­ton  researchers detected rhyth­mic activ­ity inside most neu­rons, the activ­ity pat­terns did not appear to par­tic­i­pate in posi­tion calculations.

Read the abstract.

Domnisoru, Cristina, Amina A. Kinkhab­wala & David W. Tank. 2013. Mem­brane poten­tial dynam­ics of grid cells. Nature. doi:10.1038/nature11973. Pub­lished online Feb. 10, 2013.

This work was sup­ported by the National Insti­tute of Neu­ro­log­i­cal Dis­or­ders and Stroke under award num­bers 5RC1NS068148-02 and 1R37NS081242-01, the National Insti­tute of Men­tal Health under award num­ber 5R01MH083686-04, a National Insti­tutes of Health Post­doc­toral Fel­low­ship grant F32NS070514-01A1 (A.A.K.), and a National Sci­ence Foun­da­tion Grad­u­ate Research Fel­low­ship (C.D.).