Tag Archives: engineering

Quantum computing moves forward (Science)

By Cather­ine Zan­donella, Office of the Dean for Research

New tech­nolo­gies that exploit quan­tum behav­ior for com­put­ing and other appli­ca­tions are closer than ever to being real­ized due to recent advances, accord­ing to a review arti­cle pub­lished this week in the jour­nal Sci­ence.

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A sil­i­con chip lev­i­tates indi­vid­ual atoms used in quan­tum infor­ma­tion pro­cess­ing. Photo: Curt Suplee and Emily Edwards, Joint Quan­tum Insti­tute and Uni­ver­sity of Mary­land. Credit: Science.

These advances could enable the cre­ation of immensely pow­er­ful com­put­ers as well as other appli­ca­tions, such as highly sen­si­tive detec­tors capa­ble of prob­ing bio­log­i­cal sys­tems. “We are really excited about the pos­si­bil­i­ties of new semi­con­duc­tor mate­ri­als and new exper­i­men­tal sys­tems that have become avail­able in the last decade,” said Jason Petta, one of the authors of the report and an asso­ciate pro­fes­sor of physics at Prince­ton University.

Petta co-authored the arti­cle with David Awschalom of the Uni­ver­sity of Chicago, Lee Bas­set of the Uni­ver­sity of California-Santa Bar­bara, Andrew Dzu­rak of the Uni­ver­sity of New South Wales and Eve­lyn Hu of Har­vard University.

Two sig­nif­i­cant break­throughs are enabling this for­ward progress, Petta said in an inter­view. The first is the abil­ity to con­trol quan­tum units of infor­ma­tion, known as quan­tum bits, at room tem­per­a­ture. Until recently, tem­per­a­tures near absolute zero were required, but new diamond-based mate­ri­als allow spin qubits to be oper­ated on a table top, at room tem­per­a­ture. Diamond-based sen­sors could be used to image sin­gle mol­e­cules, as demon­strated ear­lier this year by Awschalom and researchers at Stan­ford Uni­ver­sity and IBM Research (Sci­ence, 2013).

The sec­ond big devel­op­ment is the abil­ity to con­trol these quan­tum bits, or qubits, for sev­eral sec­onds before they lapse into clas­si­cal behav­ior, a feat achieved by Dzurak’s team (Nature, 2010) as well as Prince­ton researchers led by Stephen Lyon, pro­fes­sor of elec­tri­cal engi­neer­ing (Nature Mate­ri­als, 2012). The devel­op­ment of highly pure forms of sil­i­con, the same mate­r­ial used in today’s clas­si­cal com­put­ers, has enabled researchers to con­trol a quan­tum mechan­i­cal prop­erty known as “spin”. At Prince­ton, Lyon and his team demon­strated the con­trol of spin in bil­lions of elec­trons, a state known as coher­ence, for sev­eral sec­onds by using highly pure silicon-28.

Quantum-based tech­nolo­gies exploit the phys­i­cal rules that gov­ern very small par­ti­cles — such as atoms and elec­trons — rather than the clas­si­cal physics evi­dent in every­day life. New tech­nolo­gies based on “spin­tron­ics” rather than elec­tron charge, as is cur­rently used, would be much more pow­er­ful than cur­rent technologies.

In quantum-based sys­tems, the direc­tion of the spin (either up or down) serves as the basic unit of infor­ma­tion, which is anal­o­gous to the 0 or 1 bit in a clas­si­cal com­put­ing sys­tem. Unlike our clas­si­cal world, an elec­tron spin can assume both a 0 and 1 at the same time, a feat called entan­gle­ment, which greatly enhances the abil­ity to do computations.

A remain­ing chal­lenge is to find ways to trans­mit quan­tum infor­ma­tion over long dis­tances. Petta is explor­ing how to do this with col­lab­o­ra­tor Andrew Houck, asso­ciate pro­fes­sor of elec­tri­cal engi­neer­ing at Prince­ton. Last fall in the jour­nal Nature, the team pub­lished a study demon­strat­ing the cou­pling of a spin qubit to a par­ti­cle of light, known as a pho­ton, which acts as a shut­tle for the quan­tum information.

Yet another remain­ing hur­dle is to scale up the num­ber of qubits from a hand­ful to hun­dreds, accord­ing to the researchers. Sin­gle quan­tum bits have been made using a vari­ety of mate­ri­als, includ­ing elec­tronic and nuclear spins, as well as superconductors.

Some of the most excit­ing appli­ca­tions are in new sens­ing and imag­ing tech­nolo­gies rather than in com­put­ing, said Petta. “Most peo­ple agree that build­ing a real quan­tum com­puter that can fac­tor large num­bers is still a long ways out,” he said. “How­ever, there has been a change in the way we think about quan­tum mechan­ics – now we are think­ing about quantum-enabled tech­nolo­gies, such as using a spin qubit as a sen­si­tive mag­netic field detec­tor to probe bio­log­i­cal systems.”

Read the abstract.

Awschalom D.D., Bas­sett L.C., Dzu­rak A.S., Hu E.L. & Petta J.R. (2013). Quan­tum spin­tron­ics: engi­neer­ing and manip­u­lat­ing atom-like spins in semi­con­duc­tors. Sci­ence 339 (6124) 1174–1179. PMID:

The research at Prince­ton Uni­ver­sity was sup­ported by the Alfred P. Sloan Foun­da­tion, the David and Lucile Packard Foun­da­tion, US Army Research Office grant W911NF-08–1-0189, DARPA QuEST award HR0011-09–1-0007 and the US National Sci­ence Foun­da­tion through the Prince­ton Cen­ter for Com­plex Mate­ri­als (DMR-0819860) and CAREER award DMR-0846341.

How do bacteria clog medical devices? Very quickly. (PNAS)

stone-figure-2D_540A new study has exam­ined how bac­te­ria clog med­ical devices, and the result isn’t pretty. The microbes join to cre­ate slimy rib­bons that tan­gle and trap other pass­ing bac­te­ria, cre­at­ing a full block­age in a star­tlingly short period of time.

The find­ing could help shape strate­gies for pre­vent­ing clog­ging of devices such as stents — which are implanted in the body to keep open blood ves­sels and pas­sages — as well as water fil­ters and other items that are sus­cep­ti­ble to con­t­a­m­i­na­tion. The research was pub­lished in Pro­ceed­ings of the National Acad­emy of Sciences.

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Click on the image to view movie. Over a period of about 40 hours, bac­te­r­ial cells (green) flowed through a chan­nel, form­ing a green biofilm on the walls. Over the next ten hours, researchers sent red bac­te­r­ial cells through the chan­nel. The red cells became stuck in the sticky biofilm and began to form thin red stream­ers. Once stuck, these stream­ers in turn trapped addi­tional cells, lead­ing to rapid clog­ging. (Image source: Knut Drescher)

Using time-lapse imag­ing, researchers at Prince­ton Uni­ver­sity mon­i­tored fluid flow in nar­row tubes or pores sim­i­lar to those used in water fil­ters and med­ical devices. Unlike pre­vi­ous stud­ies, the Prince­ton exper­i­ment more closely mim­ic­ked the nat­ural fea­tures of the devices, using rough rather than smooth sur­faces and pressure-driven fluid instead of non-moving fluid.

The team of biol­o­gists and engi­neers intro­duced a small num­ber of bac­te­ria known to be com­mon con­t­a­m­i­nants of med­ical devices. Over a period of about 40 hours, the researchers observed that some of the microbes — dyed green for vis­i­bil­ity — attached to the inner wall of the tube and began to mul­ti­ply, even­tu­ally form­ing a slimy coat­ing called a biofilm. These films con­sist of thou­sands of indi­vid­ual cells held together by a sort of bio­log­i­cal glue.

Over the next sev­eral hours, the researchers sent addi­tional microbes, dyed red, into the tube. These red cells became stuck to the biofilm-coated walls, where the force of the flow­ing liq­uid shaped the trapped cells into stream­ers that rip­pled in the liq­uid like flags rip­pling in a breeze. Dur­ing this time, the fluid flow slowed only slightly.

At about 55 hours into the exper­i­ment, the biofilm stream­ers tan­gled with each other, form­ing a net-like bar­rier that trapped addi­tional bac­te­r­ial cells, cre­at­ing a larger bar­rier which in turn ensnared more cells. Within an hour, the entire tube became blocked and the fluid flow stopped.

The study was con­ducted by lead author Knut Drescher with assis­tance from tech­ni­cian Yi Shen. Drescher is a post­doc­toral research asso­ciate work­ing with Bon­nie Bassler, Princeton’s Squibb Pro­fes­sor in Mol­e­c­u­lar Biol­ogy and a Howard Hughes Med­ical Insti­tute Inves­ti­ga­tor, and Howard Stone, Princeton’s Don­ald R. Dixon ’69 and Eliz­a­beth W. Dixon Pro­fes­sor of Mechan­i­cal and Aero­space Engineering.

For me the sur­prise was how quickly the biofilm stream­ers caused com­plete clog­ging,” said Stone. “There was no warn­ing that some­thing bad was about to happen.”

By con­struct­ing their own con­trolled envi­ron­ment, the researchers demon­strated that rough sur­faces and pres­sure dri­ven flow are char­ac­ter­is­tics of nature and need to be taken into account exper­i­men­tally. The researchers used stents, soil-based fil­ters and water fil­ters to prove that the biofilm streams indeed form in real sce­nar­ios and likely explain why devices fail.

The work also allowed the researchers to explore which bac­te­r­ial genes con­tribute to biofilm streamer for­ma­tion. Pre­vi­ous stud­ies, con­ducted under non-realistic con­di­tions, iden­ti­fied sev­eral genes involved in for­ma­tion of the biofilm stream­ers. The Prince­ton researchers found that some of those pre­vi­ously iden­ti­fied genes were not needed for biofilm streamer for­ma­tion in the more real­is­tic habitat.

Read the abstract.

Drescher, Knut, Yi Shen, Bon­nie L. Bassler, and Howard A. Stone. 2013. Biofilm stream­ers cause cat­a­strophic dis­rup­tion of flow with con­se­quences for envi­ron­men­tal and med­ical sys­tems. Pro­ceed­ings of the National Acad­emy of Sci­ences. Pub­lished online Feb­ru­ary 11.

This work was sup­ported by the Howard Hughes Med­ical
Insti­tute, National Insti­tutes of Health grant 5R01GM065859, National Sci­ence Foun­da­tion (NSF) grant MCB-0343821, NSF grant MCB-1119232, and the Human Fron­tier Sci­ence Program.

Water filters made with copper could remove bacteria at lower cost (Journal of Applied Physics)

Porous ceramic water fil­ters are often coated with col­loidal sil­ver, which pre­vents the growth of microbes trapped in the micro– and nano-scale pores of the fil­ter. Other met­als such as cop­per and zinc have also been shown to exhibit anti-microbial activ­ity. Prince­ton University’s Wole Soboyejo and col­leagues used atomic force microscopy (AFM) mea­sure­ments to study the adhe­sion inter­ac­tion between Escherichia coli (E. coli) bac­te­ria and col­loidal sil­ver, sil­ver nanopar­ti­cles, and cop­per nanopar­ti­cles, as well as the inter­ac­tions of the bac­te­ria and the three dif­fer­ent types of metal to porous clay-based ceramic surfaces.

As reported in the May 24, 2012 issue of Jour­nal of Applied Physics, of the three antimi­cro­bial met­als stud­ied the sil­ver nanopar­ti­cles had the high­est affin­ity for E. coli bac­te­ria. The col­loidal sil­ver had the high­est affin­ity for a porous ceramic sur­face and is there­fore the least likely to leach into the fil­trate. How­ever, since the adhe­sion between col­loidal sil­ver and E. coli is in the same range as the adhe­sion between cop­per and the bac­te­ria, cop­per may have poten­tial as a less expen­sive dis­in­fec­tant coat­ing for ceramic water filters.

Source: Amer­i­can Insti­tute of Physics

A Universal Method to Produce Low–Work Function Electrodes for Organic Electronics (Science)

Read the abstract: A Uni­ver­sal Method to Pro­duce Low–Work Func­tion Elec­trodes for Organic Elec­tron­ics. Zhou, Y et al. Sci­ence 20 April 2012: 327–332. Work by researchers at Geor­gia Insti­tute of Tech­nol­ogy in col­lab­o­ra­tion with Prince­ton University’s Antoine Kahn.

The international trade of “virtual water” in the form of water-intensive crops can lead to enhanced savings in global water (PNAS)

Read the jour­nal abstract here:
Evo­lu­tion of the global vir­tual water trade net­work.
Dalin C, Konar M, Hanasaki N, Rinaldo A, Rodriguez-Iturbe I.
Proc Natl Acad Sci U S A. 2012 Apr 2. [Epub ahead of print]