Flexibility is key in mechanism of biological self-assembly

https://youtu.be/QcNC2OAKTqw By Catherine Zandonella, Office of the Dean for Research A new study has modeled a crucial first step in the self-assembly of cellular structures such as drug receptors and other protein complexes, and found that the flexibility of the structures has a dramatic impact on how fast they join together. The study, published this … Continue reading Flexibility is key in mechanism of biological self-assembly

Scientists capture the elusive structure of essential digestive enzyme (JACS)

By Tien Nguyen, Department of Chemistry Using a powerful combination of techniques from biophysics to mathematics, researchers have revealed new insights into the mechanism of a liver enzyme that is critical for human health. The enzyme, phenylalanine hydroxylase, turns the essential amino acid phenylalanine – found in eggs, beef and many other foods and as … Continue reading Scientists capture the elusive structure of essential digestive enzyme (JACS)

Chemical tracers reveal oxygen-dependent switch in cellular pathway to fat (Nature Chemical Biology)

By Tien Nguyen, Department of Chemistry Using tracer compounds, scientists have been able to track the cellular production of NADPH, a key coenzyme for making fat, through a pathway that has never been measured directly before. By tracking this pathway, known as malic enzyme metabolism, which is one of a few recognized routes to make … Continue reading Chemical tracers reveal oxygen-dependent switch in cellular pathway to fat (Nature Chemical Biology)