Changes in Greenland ice sheet over space and time (PNAS)

Polar ice sheets are melting and contributing to a global rise in sea-level. This study looked at changes in Greenland’s ice sheet from April 2002 to August 2011 and found that active areas of ice loss were concentrated on the southeastern and northwestern coasts, with ice mass in the center of Greenland steadily increasing over the decade.

Christopher Harig and Frederik J. Simons. Mapping Greenland’s mass loss in space and time. Proceedings of the National Academy of Sciences. Published online before print November 19, 2012, doi: 10.1073/pnas.1206785109

Read the abstract.

The implications of “self-boosting” vaccines on herd immunity

Researchers use mathematical models to consider the implications of “self-boosting” vaccines—a class of emerging vaccines that can establish long-term intermittent antigen presentation within a host—on herd immunity.

“Self-boosting vaccines and their implications for herd immunity” by Nimalan Arinaminpathy, et al.
10.1073/pnas.1209683109

Read the abstract

Leaks in the Pipeline: When women leave science (Proceedings of the Royal Society B)

Young women outnumber  men in most university science classes, yet the number of tenured female professors remains far below that of men. The potential causes — discrimination, biological differences, personal preferences, societal pressures, or simply the time-lags associated with long careers — have been hotly debated.

In a paper published in the Proceedings of the Royal Society B, Princeton researchers modeled academic careers to disentangle time lags from gender-based differences. Although the research does not reveal exactly why women leave science, the study does indicate when they do so.

The investigators found that the slow progression of the typical science career – with years spent in undergraduate and graduate education, postdoctoral research, and untenured professorships — accounts for much of the current underrepresentation of women.

In other words, demographic inertia – the fact that it takes both women and men many years to get to the top of the scientific career ladder – plays a large role in the lack of tenured female professors in science.

The researchers used data collected over the past three decades by the United States National Science Foundation to compare a simulated “gender-difference free” situation to the actual numbers.

The model results demonstrated that the time lags in academic careers are indeed an important factor limiting the number of female faculty, and that it is unfair to expect a 50-50 ratio at present.

However, once this time lag was factored in, there were still considerably fewer female scientists than would be expected if there were no gender differences.  The pattern held for all scientific disciplines considered, although the extent varied by discipline.

Researchers found that in most disciplines, the biggest loss of women came between their PhD and faculty positions.

In a handful of disciplines, however, the lack of females in senior positions stems from the fact that very few women enter the field as undergraduates in the first place. These fields include mathematics, computer sciences, physics, and engineering. Those that do are more likely to continue to graduate school than their male peers.

Although the model could not pinpoint specific causes for the observed gender differences, the researchers noted that the fact that these differences are still shrinking. As these differences seem to be absent at selective career transitions (such as the granting of tenure), the researchers suggest that innate gender differences are not likely to be responsible for the lack of women in senior faculty positions.

The work was conducted by Allison Shaw and Daniel Stanton. Shaw is a graduate student in the laboratory of Simon Levin, the Moffett Professor of Biology in the Department of Ecology and Evolution, and Iain Couzin, assistant professor in Ecology and Evolutionary Biology at Princeton University. Daniel Stanton earned his Ph.D. in the laboratories of Henry Horn, emeritus professor, and Lars Hedin, professor of Ecology and Evolutionary Biology at Princeton University. Stanton is now a postdoctoral researcher at Australian National University.

Shaw, AK and Stanton, DE. Leaks in the pipeline: separating demographic inertia from ongoing gender differences in academia. Proc. R. Soc. B. Published online before print June 20, 2012, doi: 10.1098/rspb.2012.0822

http://rspb.royalsocietypublishing.org/content/early/2012/06/18/rspb.2012.0822.abstract

 

How our brains keep track of where we are in the world (Journal of Neuroscience)

Libraries, supermarkets, classrooms…the world is full of places that look very similar, and yet our brains always seem to keep track of where we are. In a new study published in the Journal of Neuroscience, researchers at Princeton University and Ohio State University have uncovered one way in which the brain does this.

Similar-looking places can be distinguished from each other because of differences in what we experience when navigating to them. As we head toward a destination, our brains catalogue details such as other nearby buildings, the look of the doorway, even the people nearby.

The researchers discovered that the parahippocampal cortex, a part of the visual system that analyzes the current scene in front of us, also incorporates the details leading up to the scene, or its “temporal context.” As a result, even when two scenes look identical, we create different memory traces for them when their temporal contexts are different. Ultimately, this can help our brains to keep track of where we are in the world.

Learn more about Nicholas Turk-Browne‘s research at Princeton University.

Journal Citation: Turk-Browne NB, Simon MG, Sederberg PB. Scene representations in parahippocampal cortex depend on temporal context.  J Neurosci. 2012 May 23;32(21):7202-7.

Water filters made with copper could remove bacteria at lower cost (Journal of Applied Physics)

Porous ceramic water filters are often coated with colloidal silver, which prevents the growth of microbes trapped in the micro- and nano-scale pores of the filter. Other metals such as copper and zinc have also been shown to exhibit anti-microbial activity. Princeton University’s Wole Soboyejo and colleagues used atomic force microscopy (AFM) measurements to study the adhesion interaction between Escherichia coli (E. coli) bacteria and colloidal silver, silver nanoparticles, and copper nanoparticles, as well as the interactions of the bacteria and the three different types of metal to porous clay-based ceramic surfaces.

As reported in the May 24, 2012 issue of Journal of Applied Physics, of the three antimicrobial metals studied the silver nanoparticles had the highest affinity for E. coli bacteria. The colloidal silver had the highest affinity for a porous ceramic surface and is therefore the least likely to leach into the filtrate. However, since the adhesion between colloidal silver and E. coli is in the same range as the adhesion between copper and the bacteria, copper may have potential as a less expensive disinfectant coating for ceramic water filters.

Source: American Institute of Physics

Twenty-first-century projections of North Atlantic tropical storms from CMIP5 models (Nature Climate Change)

Efforts to predict North Atlantic hurricane activity should focus on improving the ability of global climate models to capture the processes that control patterns of sea surface temperature change through better modeling of cloud physics, atmospheric convection, oceanic processes, the role of aerosols, and overall improvements in spatial resolution of the models, according to a new study by Gabriele Villarini, a postdoctoral research associate in the Department of Civil and Environmental Engineering at Princeton University, and Gabriel A. Vecchi, a scientist at the U.S. National Oceanic and Atmospheric Administration’s Geophysical Fluid Dynamics Laboratory in Princeton.

Villarini G. and Vecchi GA. Twenty-first-century projections of North Atlantic tropical storms from CMIP5 models, Nature Climate Change
Published online 13 May 2012

Read a summary of the paper (Geophysical Fluid Dynamic Laboratory)

 

Novel drug candidates offer new route to controlling inflammation (J. Medicinal Chemistry)

An international team of researchers has designed and conducted initial tests on molecules that have the potential to treat diseases involving inflammation, such as asthma, rheumatoid arthritis, stroke and sepsis.

The team started by creating a three-dimensional map of a protein structure called the C3a receptor, which sits on the surface of human cells and plays a critical role in regulating a branch of the immune system called the complement system. They then used computational techniques to design short portions of protein molecules, known as peptides, that they predicted would interact with the receptor and either block or enhance aspects of its activity. Finally, experimentalists validated the theoretical predictions by synthesizing the peptides and testing them in animal and human cells.

The researchers – a collaboration of teams at four institutions on three continents – published their results May 10 in the Journal of Medicinal Chemistry.

The collaboration includes Christodoulos Floudas, the Stephen C. Macaleer ’63 Professor of Engineering and Applied Science in the Department of Chemical and Biological Engineering at Princeton University; Dimitrios Morikis, professor of bioengineering at the University of California, Riverside; Peter Monk of the Department of Infection and Immunity at the University of Sheffield Medical School, U.K.; and Trent Woodruff of the School of Biomedical Sciences at the University of Queensland, Australia.

Read the press release issued by Princeton University’s School of Engineering.

Read the abstract.

Study sheds light on how facial expressions evolved (Journal of Neuroscience)

A new study led by Asif Ghaz­an­far’s lab of Prince­ton Uni­ver­sity investigates the evolution of primate facial movements. They found that monkeys coordinate their facial muscles in different ways when communicating than when eating, and these distinct motor patterns implicate different neural mechanisms in the brainstem. These findings give insights into the evolutionary origins of human facial expressions.

Read the abstract: Facial Muscle Coordination in Monkeys during Rhythmic Facial Expressions and Ingestive Movements. Shepherd SA, Lanzilotto M, Ghazanfar AA. Journal of Neuroscience, 2 May 2012, 32(18): 6105-6116; doi: 10.1523/​JNEUROSCI.6136-11.2012