It slices, it dices, and it protects the body from harm (Science)

By Catherine Zandonella, Office of the Dean for Research An essential weapon in the body's fight against infection has come into sharper view. Researchers at Princeton University have discovered the 3D structure of an enzyme that cuts to ribbons the genetic material of viruses and helps defend against bacteria. The discovery of the structure of … Continue reading It slices, it dices, and it protects the body from harm (Science)

DNA Gridlock – Cells undo glitches to prevent mutations (Nature)

By Catherine Zandonella, Office of the Dean for Research Roughly six feet of DNA are packed into every human cell, so it is not surprising that our genetic material occasionally folds into odd shapes such as hairpins, crosses and clover leafs. But these structures can block the copying of DNA during cell division, leading to … Continue reading DNA Gridlock – Cells undo glitches to prevent mutations (Nature)

Cancer cells exchange leaders during invasion (PNAS)

By Catherine Zandonella, Office of the Dean for Research A new study has found that cancer cells appear to exchange leading roles as they migrate out of a tumor in the early stages of invasion, or metastasis, of other sites in the body. Metastatic cancer accounts for more than 90% of cancer-related deaths. A team … Continue reading Cancer cells exchange leaders during invasion (PNAS)

The role of breast structure in tumor development (PNAS)

Why do some breast tumors grow aggressively while others grow slowly? In this study, researchers found that the stiffness of the cells in the area around an emerging tumor influences its ability to grow and invade the breast. Using a 3-D fabrication process, the researchers created artificial breast ducts containing normal breast cells and a … Continue reading The role of breast structure in tumor development (PNAS)