Genetic instructions from mom set the pattern for embryonic development

Micrograph of a zebrafish organ called the Kupffer's vesicle

By the Department of Molecular Biology A new study indicates an essential role for a maternally inherited gene in embryonic development. The study found that zebrafish that failed to inherit specific genetic instructions from mom developed fatal defects earlier in development, even if the fish could make their own version of the gene. The study … Continue reading Genetic instructions from mom set the pattern for embryonic development

‘Acidic patch’ regulates access to genetic information

Histone image

By Pooja Makhijani for the Department of Chemistry Chromatin remodelers — protein machines that pack and unpack chromatin, the tightly wound DNA-protein complex in cell nuclei — are essential and powerful regulators for critical cellular processes, such as replication, recombination and gene transcription and repression. In a new study published Aug. 2 in the journal Nature, … Continue reading ‘Acidic patch’ regulates access to genetic information

“Kurly” protein keeps cilia moving, oriented in the right direction (Cell Reports)

By Catherine Zandonella, Office of the Dean for Research A new study of a protein found in cilia – the hair-like projections on the cell surface – may help explain how genetic defects in cilia play a role in developmental abnormalities, kidney disease and a number of other disorders. The researchers at Princeton University and … Continue reading “Kurly” protein keeps cilia moving, oriented in the right direction (Cell Reports)