Researchers’ Sudoku strategy democratizes powerful tool for genetics research (Nature Communications)

By Tien Nguyen, Department of Chemistry Researchers at Princeton and Harvard Universities have developed a way to produce the tools for figuring out gene function faster and cheaper than current methods, according to new research in the journal Nature Communications. The function of sizable chunks of many organisms’ genomes is a mystery, and figuring out … Continue reading Researchers’ Sudoku strategy democratizes powerful tool for genetics research (Nature Communications)

Revisiting the mechanics of the action potential (Nature Communications)

By Staff The action potential is widely understood as an electrical phenomenon. However, a long experimental history has documented the existence of co-propagating mechanical signatures. In a new paper in the journal Nature Communications, two Princeton University researchers have proposed a theoretical model to explain these mechanical signatures, which they term "action waves." The research … Continue reading Revisiting the mechanics of the action potential (Nature Communications)

Letting go of the (genetic) apron strings (Cell)

Researchers explore the shift from maternal genes to the embryo's genes during development By Catherine Zandonella, Office of the Dean for Research A new study from Princeton University researchers sheds light on the handing over of genetic control from mother to offspring early in development. Learning how organisms manage this transition could help researchers understand … Continue reading Letting go of the (genetic) apron strings (Cell)

Genome-wide search reveals new genes involved in long-term memory (Neuron)

By Catherine Zandonella, Office of the Dean for Research A new study has identified genes involved in long-term memory in the worm as part of research aimed at finding ways to retain cognitive abilities during aging. The study, which was published in the journal Neuron, identified more than 750 genes involved in long-term memory, including … Continue reading Genome-wide search reveals new genes involved in long-term memory (Neuron)

Caught in the act: Video system for mapping behaviors (Royal Society: Interface)

By Catherine Zandonella, Office of the Dean for Research Studies of animal behavior have come a long way from the days when scientists followed their subjects around with pen and notepad. But although cameras have replaced clipboards, evaluating the resulting videos is still a cumbersome process. To make that job easier and more comprehensive, researchers … Continue reading Caught in the act: Video system for mapping behaviors (Royal Society: Interface)

Unlocking the potential of bacterial gene clusters to discover new antibiotics (Proc. Natl. Acad. Sci.)

by Tien Nguyen, Department of Chemistry Resistance to antibiotics has been steadily rising and poses a serious threat to the stronghold of existing treatments. Now, a method from Mohammad Seyedsayamdost, an assistant professor of chemistry at Princeton University, may open the door to the discovery of a host of potential drug candidates. The vast majority … Continue reading Unlocking the potential of bacterial gene clusters to discover new antibiotics (Proc. Natl. Acad. Sci.)

Nano-dissection identifies genes involved in kidney disease (Genome Research)

By Catherine Zandonella, Office of the Dean for Research Understanding how genes act in specific tissues is critical to our ability to combat many human diseases, from heart disease to kidney failure to cancer.  Yet isolating individual cell types for study is impossible for most human tissues. A new method developed by researchers at Princeton … Continue reading Nano-dissection identifies genes involved in kidney disease (Genome Research)

A global post-transcriptional map of the elements that modulate RNA behavior (Nature)

Read the abstract here: Systematic discovery of structural elements governing stability of mammalian messenger RNAs. Goodarzi H, Najafabadi HS, Oikonomou P, Greco TM, Fish L, Salavati R, Cristea IM, Tavazoie S. Nature. 2012 Apr 8. doi: 10.1038/nature11013. [Epub ahead of print]